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>   home   >   Products   >   Primary Antibodies   >   Reptin/TIP49B/RUVB2 Antibody (C-term)   

Reptin/TIP49B/RUVB2 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Reptin/TIP49B/RUVB2 Antibody (C-term) AP1922D
    The anti-RUVBL21 Pab (Cat. #AP1922d) is used in Western blot to detect RUVBL2 in mouse kidney (left) and SK-Br-3 (right) tissue/cell line lysates.
  • WB - Reptin/TIP49B/RUVB2 Antibody (C-term) AP1922D
    Western blot analysis of RUVBL2 (arrow) using rabbit polyclonal RUVBL2 Antibody (Cat. #AP1922d). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the RUVBL2 gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y230
Other Accession Q9DE27, Q9WTM5, Q2TBU9, Q6FIB9
Reactivity Human, Mouse
Predicted Xenopus, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 51157 Da
Antigen Region 400-430 aa
Additional Information
Gene ID 10856
Other Names RuvB-like 2, 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, ECP-51, INO80 complex subunit J, Repressing pontin 52, Reptin 52, TIP49b, TIP60-associated protein 54-beta, TAP54-beta, RUVBL2, INO80J, TIP48, TIP49B
Target/Specificity This Reptin/TIP49B/RUVB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-430 amino acids from the C-terminal region of human Reptin/TIP49B/RUVB2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsReptin/TIP49B/RUVB2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms INO80J, TIP48, TIP49B
Function Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Cellular Location Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes
Tissue Location Ubiquitously expressed. Highly expressed in testis and thymus
Citations (0)

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This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.


Bauer, A., et al., EMBO J. 19(22):6121-6130 (2000).
Parfait, B., et al., Ann. Genet. 43(2):69-74 (2000).
Wood, M.A., et al., Mol. Cell 5(2):321-330 (2000).
Salzer, U., et al., Biochim. Biophys. Acta 1446(3):365-370 (1999).
Kanemaki, M., et al., J. Biol. Chem. 274(32):22437-22444 (1999).

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Cat# AP1922D
(40 western blots)
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