Mouse Shb Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6PD21 |
Other Accession | Q15464, NP_001028478.1 |
Reactivity | Mouse |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54708 Da |
Antigen Region | 68-95 aa |
Gene ID | 230126 |
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Other Names | SH2 domain-containing adapter protein B, Shb |
Target/Specificity | This Mouse Shb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-95 amino acids from the C-terminal region of mouse Shb. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Shb Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Shb |
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Function | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin- producing cells (By similarity). |
Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation. |
Tissue Location | Expressed in heart, liver, brain and kidney (at protein level). |
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Background
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity).
References
Calounova, G., et al. PLoS ONE 5 (6), E11155 (2010) :
Akerblom, B., et al. J. Endocrinol. 203(2):271-279(2009)
Mokhtari, D., et al. Biochem. Biophys. Res. Commun. 387(3):553-557(2009)
Funa, N.S., et al. Cancer Res. 69(5):2141-2148(2009)
Funa, N.S., et al. Differentiation 76(5):443-453(2008)
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