- CITATIONS: 1
|Application ||WB, IF, E|
|Calculated MW||53835 Da|
|Antigen Region||380-408 aa|
|Other Names||Forkhead box protein N3, Checkpoint suppressor 1, FOXN3, C14orf116, CHES1|
|Target/Specificity||This FOXN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-408 amino acids from the C-terminal region of human FOXN3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FOXN3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).|
Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq].
Samaan, G., et al. Biochem. Biophys. Res. Commun. 400(1):60-65(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Markowski, J., et al. Eur Arch Otorhinolaryngol 266(10):1501-1507(2009)
Schlade-Bartusiak, K., et al. Am. J. Med. Genet. A 146A (1), 117-123 (2008) :
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