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GPR109B Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GPR109B Antibody (N-term) AP19262A
    GPR109B Antibody (N-term)(Cat. #AP19262a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the GPR109B antibody detected the GPR109B protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P49019
Other Accession NP_006009.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44478 Da
Antigen Region 71-99 aa
Additional Information
Gene ID 8843
Other Names Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2, HCAR3, GPR109B, HCA3, HM74B, NIACR2
Target/Specificity This GPR109B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human GPR109B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGPR109B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCAR3
Synonyms GPR109B, HCA3, HM74B, NIACR2
Function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expression largely restricted to adipose tissue and spleen.
Research Areas
Citations (0)

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Background

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :
Mandrika, I., et al. Biochem. Biophys. Res. Commun. 395(2):281-287(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Jeninga, E.H., et al. J. Biol. Chem. 284(39):26385-26393(2009)
Ahmed, K., et al. J. Biol. Chem. 284(33):21928-21933(2009)

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$ 295.00
$ 99.00
Cat# AP19262A
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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