|Application ||WB, E|
|Calculated MW||28228 Da|
|Antigen Region||222-251 aa|
|Other Names||Kunitz-type protease inhibitor 2, Hepatocyte growth factor activator inhibitor type 2, HAI-2, Placental bikunin, SPINT2, HAI2, KOP|
|Target/Specificity||This SPINT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human SPINT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPINT2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Dong, W., et al. Int. J. Cancer 127(7):1526-1534(2010)
Bergum, C., et al. Prostate 70(13):1422-1428(2010)
Sivagnanam, M., et al. Clin. Dysmorphol. 19 (1), 48 (2010) :
Yamauchi, M., et al. Biol. Chem. 383(12):1953-1957(2002)
Itoh, H., et al. Eur. J. Biochem. 267(11):3351-3359(2000)
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