|Application ||WB, E|
|Calculated MW||35536 Da|
|Antigen Region||174-203 aa|
|Other Names||Quinone oxidoreductase PIG3, 1---, Tumor protein p53-inducible protein 3, p53-induced gene 3 protein, TP53I3, PIG3|
|Target/Specificity||This PIG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the C-terminal region of human PIG3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIG3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.
Kotsinas, A., et al. Oncogene 29 (37), 5220 (2010) :
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lee, J.H., et al. Oncogene 29(10):1431-1450(2010)
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
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