MIXL1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H2W2 |
Other Accession | Q9WUI0, NP_114150.1 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24659 Da |
Antigen Region | 122-151 aa |
Gene ID | 83881 |
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Other Names | Homeobox protein MIXL1, Homeodomain protein MIX, hMix, MIX1 homeobox-like protein 1, Mix1 homeobox-like protein, MIXL1, MIXL |
Target/Specificity | This MIXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the Central region of human MIXL1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MIXL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MIXL1 |
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Synonyms | MIXL |
Function | Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500} |
Tissue Location | Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).
References
Davis, R.P., et al. Blood 111(4):1876-1884(2008)
Drakos, E., et al. Hum. Pathol. 38(3):500-507(2007)
Hart, A.H., et al. Biochem. Biophys. Res. Commun. 333(4):1361-1369(2005)
Guo, W., et al. Blood 100(1):89-95(2002)
Sahr, K., et al. Gene 291 (1-2), 135-147 (2002) :
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