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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MIXL1 Antibody (Center)   

MIXL1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MIXL1 Antibody (Center) AP19284c
    MIXL1 Antibody (Center)(Cat. #AP19284c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the MIXL1 antibody detected the MIXL1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H2W2
Other Accession Q9WUI0, NP_114150.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24659 Da
Antigen Region 122-151 aa
Additional Information
Gene ID 83881
Other Names Homeobox protein MIXL1, Homeodomain protein MIX, hMix, MIX1 homeobox-like protein 1, Mix1 homeobox-like protein, MIXL1, MIXL
Target/Specificity This MIXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the Central region of human MIXL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMIXL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MIXL1
Synonyms MIXL
Function Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12070013, ECO:0000269|PubMed:17303500}
Tissue Location Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level).
Research Areas
Citations (0)
citation

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Background

Homeodomain proteins, such as MIXL1, are transcription factors that regulate cell fate during development (Hart et al., 2005 [PubMed 15982639]).

References

Davis, R.P., et al. Blood 111(4):1876-1884(2008)
Drakos, E., et al. Hum. Pathol. 38(3):500-507(2007)
Hart, A.H., et al. Biochem. Biophys. Res. Commun. 333(4):1361-1369(2005)
Guo, W., et al. Blood 100(1):89-95(2002)
Sahr, K., et al. Gene 291 (1-2), 135-147 (2002) :

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$ 182.50
$ 70.00
Cat# AP19284c
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