|Application ||WB, E|
|Calculated MW||56975 Da|
|Antigen Region||10-39 aa|
|Other Names||LEM domain-containing protein 2, hLEM2, LEMD2|
|Target/Specificity||This LEMD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human LEMD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LEMD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643).|
|Cellular Location||Nucleus inner membrane; Multi- pass membrane protein. Note=Lamina- associated protein residing in the inner nuclear membrane (INM) Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
LEMD2 is involved in nuclear structure organization.
Kestenbaum, B., et al. J. Am. Soc. Nephrol. 21(7):1223-1232(2010) Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) : Cotsapas, C., et al. Hum. Mol. Genet. 18(18):3502-3507(2009)
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