|Application ||WB, E|
|Calculated MW||39743 Da|
|Antigen Region||330-357 aa|
|Other Names||IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT, FCRN|
|Target/Specificity||This FCGRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-357 amino acids from the C-terminal region of human FCGRT.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCGRT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
Mezo, A.R., et al. J. Biol. Chem. 285(36):27694-27701(2010)
Freiberger, T., et al. Clin. Immunol. 136(3):419-425(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Freiberger, T., et al. J. Reprod. Immunol. 85(2):193-197(2010)
Mikulska, J.E., et al. Eur. J. Immunogenet. 27(4):231-240(2000)
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