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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   FCGRT Antibody (C-term)   

FCGRT Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FCGRT Antibody (C-term) AP19288b
    FCGRT Antibody (C-term)(Cat. #AP19288b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FCGRT antibody detected the FCGRT protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P55899
Other Accession NP_004098.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39743 Da
Antigen Region 330-357 aa
Additional Information
Gene ID 2217
Other Names IgG receptor FcRn large subunit p51, FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, FCGRT, FCRN
Target/Specificity This FCGRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-357 amino acids from the C-terminal region of human FCGRT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCGRT Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCGRT
Synonyms FCRN
Function Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein
Tissue Location Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
Research Areas
Citations (0)

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Background

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

References

Mezo, A.R., et al. J. Biol. Chem. 285(36):27694-27701(2010)
Freiberger, T., et al. Clin. Immunol. 136(3):419-425(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Freiberger, T., et al. J. Reprod. Immunol. 85(2):193-197(2010)
Mikulska, J.E., et al. Eur. J. Immunogenet. 27(4):231-240(2000)

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Cat# AP19288b
Size:
Quantity:
(40 western blots)
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