|Application ||WB, E|
|Other Accession||P47862, Q8R2N1, Q08DE6, NP_004916.1|
|Calculated MW||31544 Da|
|Antigen Region||163-191 aa|
|Other Names||Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3|
|Target/Specificity||This AQP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human AQP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AQP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).|
|Cellular Location||Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney|
|Tissue Location||Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level|
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Provided below are standard protocols that you may find useful for product applications.
Aquaporin 3 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kim, N.H., et al. J. Invest. Dermatol. 130(9):2231-2239(2010)
Ji, C., et al. Int. J. Mol. Med. 26(2):257-263(2010)
Melis, M., et al. Dis. Colon Rectum 53(6):936-943(2010)
Shen, L., et al. Biomed. Pharmacother. 64(5):313-318(2010)
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