|Application ||WB, E|
|Other Accession||P78324, NP_001077379.1|
|Calculated MW||43211 Da|
|Antigen Region||107-134 aa|
|Other Names||Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, CD172b, SIRPB1|
|Target/Specificity||This SIRPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the Central region of human SIRPB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SIRPB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in monocytes and dendritic cells.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)
Martins-de-Souza, D., et al. J Neural Transm 116(3):275-289(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
van den Berg, T.K., et al. J. Immunol. 175(12):7788-7789(2005)
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