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Mouse Rcvrn Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Rcvrn Antibody (N-term) AP19308a
    Mouse Rcvrn Antibody (N-term)(Cat. #AP19308a) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Rcvrn antibody detected the Rcvrn protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P34057
Other Accession NP_033064.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 23407 Da
Antigen Region 39-67 aa
Additional Information
Gene ID 19674
Other Names Recoverin, 23 kDa photoreceptor cell-specific protein, Cancer-associated retinopathy protein, Protein CAR, Rcvrn, Rcv1
Target/Specificity This Mouse Rcvrn antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-67 amino acids from the N-terminal region of mouse Rcvrn.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Rcvrn Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Rcvrn
Synonyms Rcv1
Function Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (PubMed:25673692). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (PubMed:15882641). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (PubMed:29435986).
Cellular Location Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (PubMed:15961391). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity) {ECO:0000250|UniProtKB:P21457, ECO:0000269|PubMed:15961391}
Tissue Location Expressed in rod photoreceptors in the retina (at protein level).
Research Areas
Citations (0)
citation

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Background

Rcvrn seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

References

Jin, K., et al. J. Neurosci. 30(36):11902-11916(2010)
Georgi, S.A., et al. J. Neurosci. 30(11):4048-4061(2010)
Sanuki, R., et al. FEBS Lett. 584(4):753-758(2010)
Brzezinski, J.A. IV, et al. Development 137(4):619-629(2010)
Chen, C.K., et al. J. Neurosci. 30(4):1213-1220(2010)

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$ 365.00
$ 140.00
Cat# AP19308a
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