|Application ||WB, E|
|Other Accession||Q4R6T3, Q9HA31|
|Calculated MW||50240 Da|
|Antigen Region||344-376 aa|
|Other Names||Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3|
|Target/Specificity||This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-376 amino acids from the C-terminal region of human EIF2B3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EIF2B3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|
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Provided below are standard protocols that you may find useful for product applications.
EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
van der Knaap, M.S., et al., Ann. Neurol. 51(2):264-270 (2002).
Kruger, M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(15):8566-8571 (2000).
Gomez, E., et al., Mol. Cell. Biol. 20(11):3965-3976 (2000).
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