|Application ||WB, E|
|Calculated MW||26132 Da|
|Antigen Region||26-55 aa|
|Other Names||Vesicle transport protein SEC20, BCL2/adenovirus E1B 19 kDa protein-interacting protein 1, Transformation-related gene 8 protein, TRG-8, BNIP1, NIP1, SEC20L|
|Target/Specificity||This BNIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human BNIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BNIP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.|
|Cellular Location||Mitochondrion. Endoplasmic reticulum membrane; Single-pass type IV membrane protein|
|Tissue Location||Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. Alternative splicing of this gene results in four protein products with identical N- and C-termini.
Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Nakajima, K., et al. EMBO J. 23(16):3216-3226(2004)
Zhang, H., et al. FEBS Lett. 448(1):23-27(1999)
Kataoka, N., et al. Nucleic Acids Res. 23(18):3638-3641(1995)
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