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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BAZ1B Antibody (N-term)   

BAZ1B Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BAZ1B Antibody (N-term) AP19326a
    BAZ1B Antibody (N-term)(Cat. #AP19326a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BAZ1B antibody detected the BAZ1B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UIG0
Other Accession NP_115784.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 170903 Da
Antigen Region 157-186 aa
Additional Information
Gene ID 9031
Other Names Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2, BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF
Target/Specificity This BAZ1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human BAZ1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBAZ1B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAZ1B
Synonyms WBSC10, WBSCR10, WBSCR9, WSTF
Function Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136} Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA
Tissue Location Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary
Research Areas
Citations (0)

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This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010)
Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :
Oya, H., et al. J. Biol. Chem. 284(47):32472-32482(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 295.00
$ 99.00
Cat# AP19326a
(40 western blots)
Availability: In Stock
Bulk Size
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