|Application ||WB, E|
|Other Accession||P23711, O70252, Q2PG53, NP_002125.3|
|Predicted||Monkey, Mouse, Rat|
|Calculated MW||36033 Da|
|Antigen Region||24-52 aa|
|Other Names||Heme oxygenase 2, HO-2, HMOX2, HO2|
|Target/Specificity||This HMOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human HMOX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HMOX2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.|
|Cellular Location||Microsome. Endoplasmic reticulum.|
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Provided below are standard protocols that you may find useful for product applications.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus.
Abdel Aziz, M.T., et al. Andrologia 42(4):236-241(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
He, J.Z., et al. J. Biol. Chem. 285(13):9452-9461(2010)
Zhong, J.L., et al. Free Radic. Biol. Med. 48(2):196-206(2010)
Yun, L., et al. Clin. Exp. Hypertens. 31(7):534-543(2009)
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