|Application ||WB, E|
|Other Accession||Q8R2Q0, NP_036233.2|
|Calculated MW||65835 Da|
|Antigen Region||336-365 aa|
|Other Names||Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC|
|Target/Specificity||This TRIM29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human TRIM29.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM29 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation.|
|Cellular Location||Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments|
|Tissue Location||Expressed in placenta, prostate and thymus.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yuan, Z., et al. Mol. Cell. Biol. 30(12):3004-3015(2010)
Chattopadhyay, I., et al. Mutat. Res. 696(2):130-138(2010)
Bertrand-Vallery, V., et al. PLoS ONE 5 (5), E10462 (2010) :
Ring, B.Z., et al. Mod. Pathol. 22(8):1032-1043(2009)
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