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APG4B Antibody (Center G254)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - APG4B Antibody (Center G254) AP19349c
    APG4B Antibody (Center G254)(Cat. #AP19349c) western blot analysis in Uterus tissue lysates (35ug/lane).This demonstrates the APG4B antibody detected the APG4B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y4P1
Other Accession Q8BGE6, Q6DG88, Q6PZ02, Q6PZ03, NP_037457
Reactivity Human
Predicted Bovine, Chicken, Zebrafish, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44294 Da
Antigen Region 239-265 aa
Additional Information
Gene ID 23192
Other Names Cysteine protease ATG4B, 3422-, AUT-like 1 cysteine endopeptidase, Autophagin-1, Autophagy-related cysteine endopeptidase 1, Autophagy-related protein 4 homolog B, hAPG4B, ATG4B, APG4B, AUTL1, KIAA0943
Target/Specificity This APG4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-265 amino acids from the Central region of human APG4B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPG4B Antibody (Center G254) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATG4B
Synonyms APG4B, AUTL1, KIAA0943
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Cellular Location Cytoplasm.
Tissue Location Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas
Research Areas
Citations (0)

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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].


Satoo, K., et al. EMBO J. 28(9):1341-1350(2009) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007) Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) : Olsen, J.V., et al. Cell 127(3):635-648(2006) Olsen, J.V., et al. Cell 127(3):635-648(2006)

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Cat# AP19349c
(40 western blots)
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