|Application ||WB, E|
|Calculated MW||51407 Da|
|Antigen Region||371-400 aa|
|Other Names||HEPACAM family member 2, Mitotic kinetics regulator, HEPACAM2, MIKI|
|Target/Specificity||This HEPACAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human HEPACAM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HEPACAM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.|
|Cellular Location||Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation)|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The function of the HEPACAM2 protein remains unknown.
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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