|Application ||WB, E|
|Other Accession||Q5FVH4, Q64362, Q4R5E1, Q5ZJJ5, NP_001012398.1|
|Predicted||Chicken, Monkey, Mouse, Rat|
|Calculated MW||33128 Da|
|Antigen Region||262-288 aa|
|Other Names||AKT-interacting protein, Ft1, Fused toes protein homolog, AKTIP, FTS|
|Target/Specificity||This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AKTIP Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.|
|Cellular Location||Cytoplasm. Cell membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Notaridou, M., et al. Int. J. Cancer (2010) In press :
Quaye, L., et al. Hum. Mol. Genet. 18(10):1869-1878(2009)
Xu, L., et al. Mol. Biol. Cell 19(12):5059-5071(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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