|Application ||WB, E|
|Calculated MW||43292 Da|
|Antigen Region||252-281 aa|
|Other Names||Homeobox protein Hox-A10, Homeobox protein Hox-18, Hoxa10, Hox-18, Hoxa-10|
|Target/Specificity||This Mouse Hoxa10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-281 amino acids from the Central region of mouse Hoxa10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Hoxa10 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'.|
|Tissue Location||Expressed in the developing limb bud where it is restricted to the mesenchyme along the proximal-distal axis Also found in developing gut and urogenital tract. In adult tissue, both forms found in kidney but only isoform 1 is expressed in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of a cluster on chromosome 6 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.
Gordon, J.A., et al. Mol. Cell. Biol. 30(14):3531-3541(2010)
Das, S.K. Mol. Reprod. Dev. 77(5):387-396(2010)
Vinagre, T., et al. Dev. Cell 18(4):655-661(2010)
Sadeghi, H., et al. Am. J. Physiol. Endocrinol. Metab. 298 (4), E889-E893 (2010) :
Mugford, J.W., et al. Dev. Biol. 333(2):312-323(2009)
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