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CDK2AP2 Antibody(Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CDK2AP2 Antibody(Center) AP19378c
    CDK2AP2 Antibody (Center)(Cat. #AP19378c) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the CDK2AP2 antibody detected the CDK2AP2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75956
Other Accession Q9CPY4, Q58CN7, NP_005842.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 13101 Da
Antigen Region 64-92 aa
Additional Information
Gene ID 10263
Other Names Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R, CDK2AP2, DOC1R
Target/Specificity This CDK2AP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human CDK2AP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDK2AP2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDK2AP2
Synonyms DOC1R
Function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity).
Cellular Location Cytoplasm. Nucleus Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules {ECO:0000250|UniProtKB:Q9CPY4}
Tissue Location Ubiquitous..
Research Areas
Citations (0)
citation

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Background

Belongs to the CDK2AP family.

References

Buajeeb, W., et al. Biochem. Biophys. Res. Commun. 315(4):998-1003(2004)
Zhang, X., et al. Biochem. Biophys. Res. Commun. 255(1):59-63(1999)

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$ 182.50
$ 70.00
Cat# AP19378c
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