CDK2AP2 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75956 |
Other Accession | Q9CPY4, Q58CN7, NP_005842.1 |
Reactivity | Human |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 13101 Da |
Antigen Region | 64-92 aa |
Gene ID | 10263 |
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Other Names | Cyclin-dependent kinase 2-associated protein 2, CDK2-associated protein 2, DOC-1-related protein, DOC-1R, CDK2AP2, DOC1R |
Target/Specificity | This CDK2AP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human CDK2AP2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CDK2AP2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CDK2AP2 |
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Synonyms | DOC1R |
Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:33283408). Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (PubMed:23781148). Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs (By similarity). Regulates microtubule organization of metaphase II oocytes (By similarity). |
Cellular Location | Cytoplasm. Nucleus Note=Accumulates in immature oocytes in the nucleus. During the first meiotic division, accumulates in the cytoplasm and localizes in dots in the vicinity of the chromosomes in a region enriched in microtubules {ECO:0000250|UniProtKB:Q9CPY4} |
Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the CDK2AP family.
References
Buajeeb, W., et al. Biochem. Biophys. Res. Commun. 315(4):998-1003(2004)
Zhang, X., et al. Biochem. Biophys. Res. Commun. 255(1):59-63(1999)
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