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BRMS1 Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BRMS1 Antibody(N-term) AP19387a
    BRMS1 Antibody (N-term)(Cat. #AP19387a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BRMS1 antibody detected the BRMS1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCU9
Other Accession Q5M7T3, Q99N20, NP_056214.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 28461 Da
Antigen Region 48-77 aa
Additional Information
Gene ID 25855
Other Names Breast cancer metastasis-suppressor 1, BRMS1
Target/Specificity This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBRMS1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRMS1
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly nuclear
Tissue Location Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies
Citations (0)

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This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.


Wu, Y., et al. Cancer Lett. 293(1):82-91(2010)
Vaidya, K.S., et al. Cancer Lett. 281(1):100-107(2009)
Frolova, N., et al. Tumour Biol. 30(3):148-159(2009)
Martins-de-Souza, D., et al. BMC Psychiatry 9, 17 (2009) :
Cicek, M., et al. Clin. Exp. Metastasis 26(3):229-237(2009)

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$ 295.00
$ 99.00
Cat# AP19387a
(40 western blots)
Availability: In Stock
Bulk Size
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