COL10A1 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q03692 |
Other Accession | NP_000484.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66158 Da |
Antigen Region | 29-58 aa |
Gene ID | 1300 |
---|---|
Other Names | Collagen alpha-1(X) chain, COL10A1 |
Target/Specificity | This COL10A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human COL10A1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | COL10A1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | COL10A1 |
---|---|
Function | Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. |
Cellular Location | Secreted, extracellular space, extracellular matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
References
Makitie, O., et al. J. Orthop. Res. 28(11):1497-1501(2010)
Wang, S., et al. Connect. Tissue Res. 51(3):188-196(2010)
Videman, T., et al. Arthritis Rheum. 60(2):470-481(2009)
Higashikawa, A., et al. Arthritis Rheum. 60(1):166-178(2009)
Zimmermann, P., et al. Arthritis Rheum. 58(9):2743-2753(2008)
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