|Application ||WB, E|
|Calculated MW||66158 Da|
|Antigen Region||29-58 aa|
|Other Names||Collagen alpha-1(X) chain, COL10A1|
|Target/Specificity||This COL10A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-58 amino acids from the N-terminal region of human COL10A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL10A1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
Makitie, O., et al. J. Orthop. Res. 28(11):1497-1501(2010)
Wang, S., et al. Connect. Tissue Res. 51(3):188-196(2010)
Videman, T., et al. Arthritis Rheum. 60(2):470-481(2009)
Higashikawa, A., et al. Arthritis Rheum. 60(1):166-178(2009)
Zimmermann, P., et al. Arthritis Rheum. 58(9):2743-2753(2008)
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