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SMYD5 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SMYD5 Antibody(C-term) AP19403b
    SMYD5 Antibody (C-term)(Cat. #AP19403b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SMYD5 antibody detected the SMYD5 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6GMV2
Other Accession Q3TYX3, NP_006053.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 47341 Da
Antigen Region 343-371 aa
Additional Information
Gene ID 10322
Other Names SET and MYND domain-containing protein 5, 211-, Protein NN8-4AG, Retinoic acid-induced protein 15, SMYD5, RAI15
Target/Specificity This SMYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human SMYD5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMYD5 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMYD5
Synonyms RAI15
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self- renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459).
Research Areas
Citations (0)
citation

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Background

SMYD5 contains 1 MYND-type zinc finger and 1 SET domain. The exact function of SMYD5 remains unknown.

References

Shago, M., et al. Mol. Cell. Biol. 16(8):4337-4348(1996)

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$ 182.50
$ 70.00
Cat# AP19403b
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