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SSH1 Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SSH1 Antibody(N-term) AP19412a
    SSH1 Antibody (N-term)(Cat. #AP19412a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SSH1 antibody detected the SSH1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WYL5
Other Accession Q76I79, NP_061857.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 115511 Da
Antigen Region 227-254 aa
Additional Information
Gene ID 54434
Other Names Protein phosphatase Slingshot homolog 1, SSH-like protein 1, SSH-1L, hSSH-1L, SSH1, KIAA1298, SSH1L
Target/Specificity This SSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human SSH1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSSH1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SSH1
Synonyms KIAA1298, SSH1L
Function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion Also localized to the cleavage furrow and the midbody during cytokinesis
Research Areas
Citations (0)

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The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).


Song, S.Y., et al. APMIS 118(5):389-393(2010)
Peterburs, P., et al. Cancer Res. 69(14):5634-5638(2009)
Kligys, K., et al. Biochem. Biophys. Res. Commun. 383(4):450-454(2009)
Kim, J.S., et al. Mol. Biol. Cell 20(11):2650-2660(2009)
Huang, T.Y., et al. Dev. Cell 15(5):691-703(2008)

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$ 295.00
$ 99.00
Cat# AP19412a
(40 western blots)
Availability: In Stock
Bulk Size
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