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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CCNDBP1 Antibody(N-term)   

CCNDBP1 Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCNDBP1 Antibody(N-term) AP19416a
    CCNDBP1 Antibody (N-term)(Cat. #AP19416a) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCNDBP1 antibody detected the CCNDBP1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95273
Other Accession Q4R809, NP_036274.3
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 40262 Da
Antigen Region 21-49 aa
Additional Information
Gene ID 23582
Other Names Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM
Target/Specificity This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNDBP1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms DIP1, GCIP, HHM
Function May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
Research Areas
Citations (0)

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This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].


Lee, I., et al. Cancer Res. 70(11):4357-4365(2010)
Seto, A., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 1), 21-24 (2009) :
Ikushima, H., et al. EMBO J. 27(22):2955-2965(2008)
Chen, W.C., et al. Histopathology 53(5):554-560(2008)
Chang, T.W., et al. Oncogene 27(3):332-338(2008)

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$ 295.00
$ 99.00
Cat# AP19416a
(40 western blots)
Availability: In Stock
Bulk Size
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