DHODH Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q02127 |
Other Accession | NP_001352.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42867 Da |
Antigen Region | 166-194 aa |
Gene ID | 1723 |
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Other Names | Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase, DHODH |
Target/Specificity | This DHODH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human DHODH. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DHODH Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DHODH |
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Function | Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. |
Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
References
Hail, N. Jr., et al. Free Radic. Biol. Med. 49(1):109-116(2010)
Ng, S.B., et al. Nat. Genet. 42(1):30-35(2010)
Grabar, P.B., et al. Ann. Rheum. Dis. 68(8):1367-1368(2009)
Pawlik, A., et al. Pharmacogenomics 10(2):303-309(2009)
Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :
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