|Application ||WB, E|
|Calculated MW||42867 Da|
|Antigen Region||166-194 aa|
|Other Names||Dihydroorotate dehydrogenase (quinone), mitochondrial, DHOdehase, Dihydroorotate oxidase, DHODH|
|Target/Specificity||This DHODH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human DHODH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DHODH Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|
|Cellular Location||Mitochondrion inner membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.
Hail, N. Jr., et al. Free Radic. Biol. Med. 49(1):109-116(2010)
Ng, S.B., et al. Nat. Genet. 42(1):30-35(2010)
Grabar, P.B., et al. Ann. Rheum. Dis. 68(8):1367-1368(2009)
Pawlik, A., et al. Pharmacogenomics 10(2):303-309(2009)
Anney, R.J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1369-1378 (2008) :
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