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ZHX1 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UKY1 |
| Other Accession | Q8R515, P70121, NP_009153.3 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98098 Da |
| Antigen Region | 771-800 aa |
| Gene ID | 11244 |
|---|---|
| Other Names | Zinc fingers and homeoboxes protein 1, ZHX1 |
| Target/Specificity | This ZHX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 771-800 amino acids from the C-terminal region of human ZHX1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZHX1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZHX1 |
|---|---|
| Function | Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12237128, ECO:0000269|PubMed:17056598} Note=Colocalized in the nucleus with DNMT3B |
| Tissue Location | Ubiquitously expressed. Expressed in podocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.
References
Wienk, H., et al. Biochemistry 48(21):4431-4439(2009)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Kim, S.H., et al. Biochem. Biophys. Res. Commun. 355(2):318-323(2007)
Liu, G., et al. J. Biol. Chem. 281(51):39681-39692(2006)
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