|Application ||WB, E|
|Calculated MW||85494 Da|
|Antigen Region||718-745 aa|
|Other Names||Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, MP86, Protein kinase minibrain homolog, MNBH, Dyrk1a, Dyrk|
|Target/Specificity||This Mouse Dyrk1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-745 amino acids from the C-terminal region of mouse Dyrk1a.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Dyrk1a Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3.|
|Cellular Location||Nucleus speckle|
|Tissue Location||Detected in brain (at protein level). Expressed in a variety of embryonic and adult tissues. Expressed abundantly in neurons of the brain, spinal cord, and retina in developing embryos.|
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Provided below are standard protocols that you may find useful for product applications.
Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
Park, J., et al. J. Biol. Chem. 285(41):31895-31906(2010)
Guo, X., et al. J. Biol. Chem. 285(17):13223-13232(2010)
Kurabayashi, N., et al. Mol. Cell. Biol. 30(7):1757-1768(2010)
Lee, Y., et al. J. Biol. Chem. 284(48):33343-33351(2009)
Noll, C., et al. PLoS ONE 4 (10), E7540 (2009) :
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