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Cleavage stimulation factor 2 (CSTF2) Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Cleavage stimulation factor 2 (CSTF2) Antibody (N-term) AP1942a
    Western blot analysis of anti-CSTF2 Antibody (N-term) (Cat.#AP1942a) in NCI-H460 cell line lysates (35ug/lane). CSTF2(arrow) was detected using the purified Pab.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P33240
Other Accession Q8C7E9, Q9H0L4, Q8BIQ5, Q8HXM1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 60959 Da
Antigen Region 31-60 aa
Additional Information
Gene ID 1478
Other Names Cleavage stimulation factor subunit 2, CF-1 64 kDa subunit, Cleavage stimulation factor 64 kDa subunit, CSTF 64 kDa subunit, CstF-64, CSTF2
Target/Specificity This Cleavage stimulation factor 2 (CSTF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human Cleavage stimulation factor 2 (CSTF2).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCleavage stimulation factor 2 (CSTF2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSTF2
Function One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
Cellular Location Nucleus. Note=Localized with DDX1 in cleavage bodies
Research Areas
Citations (0)
citation

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Background

CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.

References

Takagaki, Y., et al., Mol. Cell 2(6):761-771 (1998).
Martincic, K., et al., Proc. Natl. Acad. Sci. U.S.A. 95(19):11095-11100 (1998).
Takagaki, Y., et al., Cell 87(5):941-952 (1996).
Takagaki, Y., et al., Nature 372(6505):471-474 (1994).
Takagaki, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 89(4):1403-1407 (1992).

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$ 182.50
$ 70.00
Cat# AP1942a
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