|Application ||WB, E|
|Other Accession||Q8C7E9, Q9H0L4, Q8BIQ5, Q8HXM1|
|Calculated MW||60959 Da|
|Antigen Region||31-60 aa|
|Other Names||Cleavage stimulation factor subunit 2, CF-1 64 kDa subunit, Cleavage stimulation factor 64 kDa subunit, CSTF 64 kDa subunit, CstF-64, CSTF2|
|Target/Specificity||This Cleavage stimulation factor 2 (CSTF2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human Cleavage stimulation factor 2 (CSTF2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Cleavage stimulation factor 2 (CSTF2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).|
|Cellular Location||Nucleus. Note=Localized with DDX1 in cleavage bodies|
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Provided below are standard protocols that you may find useful for product applications.
CSTF2 is one of three (including CSTF1 and CSTF3) cleavage stimulation factors which combine to form CSTF which is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. CSTF2 contains a ribonucleoprotein-type RNA binding domain. CSTF2 is upregulated during activation of B cells which results in the switch of IgM heavy chain mRNA from membrane bound form to the secreted form.
Takagaki, Y., et al., Mol. Cell 2(6):761-771 (1998).
Martincic, K., et al., Proc. Natl. Acad. Sci. U.S.A. 95(19):11095-11100 (1998).
Takagaki, Y., et al., Cell 87(5):941-952 (1996).
Takagaki, Y., et al., Nature 372(6505):471-474 (1994).
Takagaki, Y., et al., Proc. Natl. Acad. Sci. U.S.A. 89(4):1403-1407 (1992).
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