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ZNF410 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZNF410 Antibody(C-term) AP19435b
    ZNF410 Antibody (C-term)(Cat. #AP19435b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the ZNF410 antibody detected the ZNF410 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q86VK4
Other Accession NP_067011.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52113 Da
Antigen Region 448-477 aa
Additional Information
Gene ID 57862
Other Names Zinc finger protein 410, Another partner for ARF 1, Zinc finger protein APA-1, ZNF410, APA1
Target/Specificity This ZNF410 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-477 amino acids from the C-terminal region of human ZNF410.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZNF410 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZNF410 {ECO:0000303|PubMed:33301730, ECO:0000312|HGNC:HGNC:20144}
Function Transcription factor that binds to the sequence motif 5'- CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).
Cellular Location Nucleus. Chromosome. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'.
Tissue Location Widely expressed..
Citations (0)
citation

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Background

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hubner, R.A., et al. Int. J. Cancer 123(3):586-593(2008)
Benanti, J.A., et al. Mol. Cell. Biol. 22(21):7385-7397(2002)

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$ 182.50
$ 70.00
Cat# AP19435b
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