ZNF410 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q86VK4 |
Other Accession | NP_067011.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52113 Da |
Antigen Region | 448-477 aa |
Gene ID | 57862 |
---|---|
Other Names | Zinc finger protein 410, Another partner for ARF 1, Zinc finger protein APA-1, ZNF410, APA1 |
Target/Specificity | This ZNF410 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-477 amino acids from the C-terminal region of human ZNF410. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ZNF410 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ZNF410 {ECO:0000303|PubMed:33301730, ECO:0000312|HGNC:HGNC:20144} |
---|---|
Function | Transcription factor that binds to the sequence motif 5'- CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730). |
Cellular Location | Nucleus. Chromosome. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'. |
Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hubner, R.A., et al. Int. J. Cancer 123(3):586-593(2008)
Benanti, J.A., et al. Mol. Cell. Biol. 22(21):7385-7397(2002)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.