|Application ||WB, E|
|Calculated MW||23420 Da|
|Antigen Region||29-57 aa|
|Other Names||Guanylyl cyclase-activating protein 2, GCAP 2, Guanylate cyclase activator 1B, GUCA1B, GCAP2|
|Target/Specificity||This GUCA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human GUCA1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GUCA1B Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.|
|Cellular Location||Cell membrane. Note=Membranes of outer segment|
|Tissue Location||Retina. Cones and rod.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq].
Sato, M., et al. Graefes Arch. Clin. Exp. Ophthalmol. 243(3):235-242(2005)
Nishiguchi, K.M., et al. Invest. Ophthalmol. Vis. Sci. 45(11):3863-3870(2004)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :
Zhang, Q.J., et al. Yi Chuan 24(1):19-21(2002)
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