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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VAPA Antibody(C-term)   

VAPA Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - VAPA Antibody(C-term) AP19461b
    VAPA Antibody (C-term) (Cat. #AP19461b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the VAPA antibody detected the VAPA protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9P0L0
Other Accession Q9Z270, Q9WV55, NP_003565.4
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 27893 Da
Antigen Region 182-210 aa
Additional Information
Gene ID 9218
Other Names Vesicle-associated membrane protein-associated protein A, VAMP-A, VAMP-associated protein A, VAP-A, 33 kDa VAMP-associated protein, VAP-33, VAPA, VAP33
Target/Specificity This VAPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-210 amino acids from the C-terminal region of human VAPA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVAPA Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAPA
Synonyms VAP33
Function Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).
Cellular Location Endoplasmic reticulum membrane; Single- pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells
Tissue Location Ubiquitous.
Research Areas
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Background

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

References

Furuita, K., et al. J. Biol. Chem. 285(17):12961-12970(2010)
Tuuf, J., et al. Biochem. Biophys. Res. Commun. 388(2):395-399(2009)
Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Prosser, D.C., et al. J. Cell. Sci. 121 (PT 18), 3052-3061 (2008) :
Lohoff, F.W., et al. J Neural Transm 115(9):1339-1345(2008)

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$ 295.00
$ 99.00
Cat# AP19461b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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