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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   DNER Antibody(C-term)   

DNER Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DNER Antibody(C-term) AP19467b
    DNER Antibody (C-term) (Cat. #AP19467b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the DNER antibody detected the DNER protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8NFT8
Other Accession Q8JZM4, NP_620711.3
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 708-736 aa
Additional Information
Other Names Delta and Notch-like epidermal growth factor-related receptor, DNER, BET
Target/Specificity This DNER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 708-736 amino acids from the C-terminal region of human DNER.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDNER Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNER
Synonyms BET
Function Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).
Tissue Location Expressed in brain, spinal cord and adrenal gland. EMBL; AF442487; AAM21557.1; -; mRNA EMBL; AY358891; AAQ89250.1; -; mRNA EMBL; AC007559; AAY14939.1; -; Genomic_DNA EMBL; AC007748; AAY24263.1; -; Genomic_DNA EMBL; AC008273; AAF19247.2; -; Genomic_DNA EMBL; AC093384; AAY14680.1; -; Genomic_DNA EMBL; CH471063; EAW70893.1; -; Genomic_DNA EMBL; BC024766; AAH24766.2; -; mRNA EMBL; BC035009; AAH35009.1; -; mRNA EMBL; AL137311; CAB70690.1; -; mRNA CCDS; CCDS33390.1; - PIR; T46247; T46247 RefSeq; NP_620711.3; NM_139072.3 UniGene; Hs.234074; - ProteinModelPortal; Q8NFT8; - SMR; Q8NFT8; - BioGrid; 124973; 1 DIP; DIP-46249N; - IntAct; Q8NFT8; 4 STRING; 9606.ENSP00000345229; - iPTMnet; Q8NFT8; - PhosphoSitePlus; Q8NFT8; - BioMuta; DNER; - DMDM; 74730301; - EPD; Q8NFT8; - MaxQB; Q8NFT8; - PaxDb; Q8NFT8; - PeptideAtlas; Q8NFT8; - PRIDE; Q8NFT8; - ProteomicsDB; 73354; - Ensembl; ENST00000341772; ENSP00000345229; ENSG00000187957 GeneID; 92737; - KEGG; hsa:92737; - UCSC; uc002vpv.4; human CTD; 92737; - DisGeNET; 92737; - EuPathDB; HostDB:ENSG00000187957.7; - GeneCards; DNER; - HGNC; HGNC:24456; DNER HPA; HPA017320; - MIM; 607299; gene neXtProt; NX_Q8NFT8; - OpenTargets; ENSG00000187957; - PharmGKB; PA162383959; - eggNOG; ENOG410IR71; Eukaryota eggNOG; ENOG410ZUAK; LUCA GeneTree; ENSGT00910000144018; - HOVERGEN; HBG060866; - InParanoid; Q8NFT8; - OMA; KDPCANV; - OrthoDB; EOG091G01VZ; - PhylomeDB; Q8NFT8; - TreeFam; TF351322; - Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus SignaLink; Q8NFT8; - SIGNOR; Q8NFT8; - ChiTaRS; DNER; human GeneWiki; DNER; - GenomeRNAi; 92737; - PRO; PR:Q8NFT8; - Proteomes; UP000005640; Chromosome 2 Bgee; ENSG00000187957; - Genevisible; Q8NFT8; HS GO; GO:0030425; C:dendrite; IDA:UniProtKB GO; GO:0005769; C:early endosome; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0043025; C:neuronal cell body; IEA:Ensembl GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB GO; GO:0030276; F:clathrin binding; TAS:UniProtKB GO; GO:0005112; F:Notch binding; IEA:Ensembl GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB GO; GO:0007417; P:central nervous system development; IEP:UniProtKB GO; GO:0006897; P:endocytosis; NAS:UniProtKB GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl GO; GO:0001764; P:neuron migration; NAS:UniProtKB GO; GO:0007220; P:Notch receptor processing; IEA:Ensembl GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl GO; GO:0007416; P:synapse assembly; NAS:UniProtKB InterPro; IPR001881; EGF-like_Ca-bd_dom InterPro; IPR013032; EGF-like_CS InterPro; IPR000742; EGF-like_dom InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site InterPro; IPR018097; EGF_Ca-bd_CS InterPro; IPR009030; Growth_fac_rcpt_cys_sf Pfam; PF00008; EGF; 6 Pfam; PF12661; hEGF; 1 SMART; SM00181; EGF; 10 SMART; SM00179; EGF_CA; 7 SUPFAM; SSF57184; SSF57184; 2 PROSITE; PS00010; ASX_HYDROXYL; 2 PROSITE; PS00022; EGF_1; 10 PROSITE; PS01186; EGF_2; 7 PROSITE; PS50026; EGF_3; 10 PROSITE; PS01187; EGF_CA; 2 1: Evidence at protein level; Activator; Calcium; Cell membrane; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 34 CHAIN 35 737 Delta and Notch-like epidermal growth factor-related receptor /FTId=PRO_0000253557 TOPO_DOM 35 640 Extracellular. TRANSMEM 641 661 Helical. TOPO_DOM 662 737 Cytoplasmic. DOMAIN 44 92 EGF-like 1. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 94 133 EGF-like 2. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 309 348 EGF-like 3. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 349 390 EGF-like 4. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 392 428 EGF-like 5. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 430 466 EGF-like 6. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 468 503 EGF-like 7. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 505 541 EGF-like 8; calcium-binding {ECO:0000255|PROSITE-ProRule:PRU00076} DOMAIN 543 579 EGF-like 9. {ECO:0000255|PROSITE- ProRule:PRU00076} DOMAIN 546 568 Follistatin-like DOMAIN 581 617 EGF-like 10; calcium-binding {ECO:0000255|PROSITE-ProRule:PRU00076} REGION 44 133 Interaction with NOTCH1. REGION 677 680 Interaction with AP1G1 and somatodendritic targeting. MOD_RES 685 685 Phosphoserine {ECO:0000250|UniProtKB:Q8JZM4} MOD_RES 711 711 Phosphotyrosine {ECO:0000250|UniProtKB:Q8JZM4} MOD_RES 721 721 Phosphotyrosine {ECO:0000250|UniProtKB:Q8JZM4} MOD_RES 722 722 Phosphoserine {ECO:0000250|UniProtKB:Q8JZM4} CARBOHYD 223 223 N-linked (GlcNAc...) asparagine CARBOHYD 564 564 N-linked (GlcNAc...) asparagine DISULFID 48 59 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 53 80 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 82 91 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 98 108 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 103 121 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 123 132 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 319 336 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 338 347 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 353 364 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 358 378 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 380 389 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 396 407 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 401 416 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 418 427 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 434 445 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 439 454 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 456 465 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 472 482 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 477 491 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 493 502 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 509 520 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 514 529 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 531 540 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 547 558 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 552 567 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 569 578 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 585 596 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 590 605 {ECO:0000255|PROSITE-ProRule:PRU00076} DISULFID 607 616 {ECO:0000255|PROSITE-ProRule:PRU00076} VARIANT 433 433 P -> L (in dbSNP:rs17853365) /FTId=VAR_028380 SEQUENCE 737 AA; 78475 MW; 25A8A8A3044308BE CRC64; MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Research Areas
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Background

Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).

References

Kurisu, J., et al. J. Neurochem. 113(6):1598-1610(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Park, J.R., et al. Cell Prolif. 43(1):19-28(2010)
Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)

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$ 295.00
$ 99.00
Cat# AP19467b
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(40 western blots)
Availability: In Stock
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