|Application ||WB, E|
|Other Accession||Q8JZM4, NP_620711.3|
|Calculated MW||78475 Da|
|Antigen Region||708-736 aa|
|Other Names||Delta and Notch-like epidermal growth factor-related receptor, DNER, BET|
|Target/Specificity||This DNER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 708-736 amino acids from the C-terminal region of human DNER.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNER Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).|
|Tissue Location||Expressed in brain, spinal cord and adrenal gland.|
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Provided below are standard protocols that you may find useful for product applications.
Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
Kurisu, J., et al. J. Neurochem. 113(6):1598-1610(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Park, J.R., et al. Cell Prolif. 43(1):19-28(2010)
Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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