|Application ||WB, E|
|Calculated MW||60158 Da|
|Antigen Region||483-509 aa|
|Other Names||Beta-galactoside alpha-2, 6-sialyltransferase 2, Alpha 2, 6-ST 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 2, ST6Gal II, ST6GalII, hST6Gal II, Sialyltransferase 2, ST6GAL2, KIAA1877, SIAT2|
|Target/Specificity||This ST6GAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-509 amino acids from the C-terminal region of human ST6GAL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ST6GAL2 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein|
|Tissue Location||Weakly expressed in some tissues, such as small intestine, colon and fetal brain|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Sialyltransferases, such as ST6GAL2 (EC 22.214.171.124), are type II transmembrane proteins that catalyze the transfer of sialic acid from CMP-sialic acid to an acceptor carbohydrate, usually to the terminal ends of carbohydrate chains.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)
Lehoux, S., et al. Glycoconj. J. 27(1):99-114(2010)
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Krzewinski-Recchi, M.A., et al. Eur. J. Biochem. 270(5):950-961(2003)
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