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>   home   >   Products   >   Primary Antibodies   >   ST6GALNAC5 Antibody(C-term)   

ST6GALNAC5 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ST6GALNAC5 Antibody(C-term) AP19473b
    ST6GALNAC5 Antibody (C-term) (Cat. #AP19473b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ST6GALNAC5 antibody detected the ST6GALNAC5 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BVH7
Other Accession NP_112227.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38443 Da
Antigen Region 110-138 aa
Additional Information
Gene ID 81849
Other Names Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 5, 2499-, GD1 alpha synthase, GalNAc alpha-2, 6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, ST6GALNAC5, SIAT7E
Target/Specificity This ST6GALNAC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the C-terminal region of human ST6GALNAC5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsST6GALNAC5 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ST6GALNAC5
Synonyms SIAT7E
Function Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N- acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl- (1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)- beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675).
Cellular Location Golgi apparatus membrane; Single- pass type II membrane protein
Citations (0)
citation

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Background

ST6GALNAC5 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)
Tsuchida, A., et al. J. Biol. Chem. 278(25):22787-22794(2003)
Ikehara, Y., et al. FEBS Lett. 463 (1-2), 92-96 (1999) :
Okajima, T., et al. J. Biol. Chem. 274(43):30557-30562(1999)

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$ 365.00
$ 140.00
Cat# AP19473b
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