ST6GALNAC5 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BVH7 |
Other Accession | NP_112227.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38443 Da |
Antigen Region | 110-138 aa |
Gene ID | 81849 |
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Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 5, 2499-, GD1 alpha synthase, GalNAc alpha-2, 6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, ST6GALNAC5, SIAT7E |
Target/Specificity | This ST6GALNAC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the C-terminal region of human ST6GALNAC5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ST6GALNAC5 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ST6GALNAC5 |
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Synonyms | SIAT7E |
Function | Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N- acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl- (1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)- beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
ST6GALNAC5 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)
Tsuchida, A., et al. J. Biol. Chem. 278(25):22787-22794(2003)
Ikehara, Y., et al. FEBS Lett. 463 (1-2), 92-96 (1999) :
Okajima, T., et al. J. Biol. Chem. 274(43):30557-30562(1999)
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