|Application ||WB, E|
|Calculated MW||46207 Da|
|Antigen Region||366-394 aa|
|Other Names||Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha, CDw116, CD116, CSF2RA, CSF2R, CSF2RY|
|Target/Specificity||This CSF2RA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-394 amino acids from the C-terminal region of human CSF2RA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSF2RA Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Isoform 4: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Mirza, S., et al. Biochem. J. 426(3):307-317(2010)
Sun, S., et al. Brain Res. 1268, 13-16 (2009) :
Suzuki, T., et al. J. Exp. Med. 205(12):2703-2710(2008)
Martinez-Moczygemba, M., et al. J. Exp. Med. 205(12):2711-2716(2008)
Hansen, G., et al. Cell 134(3):496-507(2008)
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