|Application ||WB, E|
|Calculated MW||52058 Da|
|Antigen Region||293-320 aa|
|Other Names||tRNA modification GTPase GTPBP3, mitochondrial, GTP-binding protein 3, Mitochondrial GTP-binding protein 1, GTPBP3, MTGP1|
|Target/Specificity||This GTPBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human GTPBP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GTPBP3 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.|
|Tissue Location||Ubiquitously expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described.
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
Villarroya, M., et al. Mol. Cell. Biol. 28(24):7514-7531(2008)
Bykhovskaya, Y., et al. Mol. Genet. Metab. 83(3):199-206(2004)
Li, X., et al. Biochem. Biophys. Res. Commun. 312(3):747-754(2003)
Li, X., et al. Mol. Cell. Biol. 22(21):7701-7711(2002)
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