|Application ||WB, E|
|Calculated MW||30122 Da|
|Antigen Region||150-179 aa|
|Other Names||NKG2D ligand 4, N2DL-4, NKG2DL4, Lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, RL-4, Retinoic acid early transcript 1E, RAET1E, LETAL, N2DL4, ULBP4|
|Target/Specificity||This RAET1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human RAET1E.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAET1E Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||LETAL, N2DL4, ULBP4|
|Function||Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand for NKG2D (KLRK1; MIM 611817), which is expressed on the surface of several types of immune cells and is involved in innate and adaptive immune responses (summary by Radosavljevic et al. (2002) [PubMed 11827464] and Cao et al. (2007) [PubMed 17470428]).
McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)
Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Romphruk, A.V., et al. Immunogenetics 61(9):611-617(2009)
Kong, Y., et al. Blood 114(2):310-317(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.