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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   RAET1E Antibody(Center)   

RAET1E Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - RAET1E Antibody(Center) AP19552c
    RAET1E Antibody (Center) (Cat. #AP19552c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the RAET1E antibody detected the RAET1E protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TD07
Other Accession NP_631904.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30122 Da
Antigen Region 150-179 aa
Additional Information
Gene ID 135250
Other Names NKG2D ligand 4, N2DL-4, NKG2DL4, Lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, RL-4, Retinoic acid early transcript 1E, RAET1E, LETAL, N2DL4, ULBP4
Target/Specificity This RAET1E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-179 amino acids from the Central region of human RAET1E.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAET1E Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms LETAL, N2DL4, ULBP4
Function Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid
Research Areas
Citations (0)

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Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. RAET1E is a ligand for NKG2D (KLRK1; MIM 611817), which is expressed on the surface of several types of immune cells and is involved in innate and adaptive immune responses (summary by Radosavljevic et al. (2002) [PubMed 11827464] and Cao et al. (2007) [PubMed 17470428]).


McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)
Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Romphruk, A.V., et al. Immunogenetics 61(9):611-617(2009)
Kong, Y., et al. Blood 114(2):310-317(2009)

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$ 295.00
$ 99.00
Cat# AP19552c
(40 western blots)
Availability: In Stock
Bulk Size
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