|Application ||WB, E|
|Other Accession||Q95L11, A6H8H5, Q4ZHA6, NP_004761.2|
|Predicted||Mouse, Rabbit, Bovine|
|Calculated MW||102563 Da|
|Antigen Region||138-166 aa|
|Other Names||Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv22, KCNB2|
|Target/Specificity||This KCNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human KCNB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCNB2 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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