|Application ||WB, E|
|Other Accession||Q9JLZ9, Q9WTP9, NP_036608.1|
|Calculated MW||30874 Da|
|Antigen Region||138-166 aa|
|Other Names||Ventral anterior homeobox 2, VAX2|
|Target/Specificity||This VAX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the Central region of human VAX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAX2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Holland, P.W., et al. BMC Biol. 5, 47 (2007) :
Beaty, T.H., et al. Hum. Genet. 120(4):501-518(2006)
Barbieri, A.M., et al. Proc. Natl. Acad. Sci. U.S.A. 96(19):10729-10734(1999)
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