GSTT2 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | P0CG29 |
Other Accession | P0CG30, NP_000845.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27506 Da |
Antigen Region | 113-141 aa |
Gene ID | 2953 |
---|---|
Other Names | Glutathione S-transferase theta-2, GST class-theta-2, GSTT2 |
Target/Specificity | This GSTT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-141 amino acids from the Central region of human GSTT2. |
Dilution | WB~~1:1000 IHC-P~~1:100 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GSTT2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GSTT2 |
---|---|
Function | Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1417752). Has a sulfatase activity (PubMed:1417752). |
Cellular Location | Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:P30713} |
Tissue Location | Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
References
Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)
Canova, C., et al. Tumori 96(1):1-10(2010)
Wang, S., et al. Ann. Hum. Genet. 74(1):46-56(2010)
Gemignani, F., et al. Mutat. Res. 671 (1-2), 76-83 (2009) :
Tatemichi, M., et al. J. Hum. Genet. 54(10):557-563(2009)
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