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TNNC2 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TNNC2 Antibody(C-term) AP19581b
    TNNC2 Antibody (C-term) (Cat. #AP19581b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TNNC2 antibody detected the TNNC2 protein (arrow).
    detail
  • WB - TNNC2 Antibody(C-term) AP19581b
    TNNC2 Antibody (C-term) (Cat. #AP19581b) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the TNNC2 antibody detected the TNNC2 protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P02585
Other Accession NP_003270.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 18122 Da
Antigen Region 97-126 aa
Additional Information
Gene ID 7125
Other Names Troponin C, skeletal muscle, TNNC2
Target/Specificity This TNNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the C-terminal region of human TNNC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNNC2 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNNC2
Function Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Research Areas
Citations (0)
citation

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Background

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.

References

Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Robinson, P., et al. FASEB J. 21(3):896-905(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Vassylyev, D.G., et al. Proc. Natl. Acad. Sci. U.S.A. 95(9):4847-4852(1998)

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$ 365.00
$ 140.00
Cat# AP19581b
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