|Application ||WB, E|
|Calculated MW||18122 Da|
|Antigen Region||97-126 aa|
|Other Names||Troponin C, skeletal muscle, TNNC2|
|Target/Specificity||This TNNC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-126 amino acids from the C-terminal region of human TNNC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNNC2 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.|
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Provided below are standard protocols that you may find useful for product applications.
Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Robinson, P., et al. FASEB J. 21(3):896-905(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Vassylyev, D.G., et al. Proc. Natl. Acad. Sci. U.S.A. 95(9):4847-4852(1998)
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