|Application ||WB, E|
|Calculated MW||51056 Da|
|Antigen Region||404-432 aa|
|Other Names||Glucoside xylosyltransferase 2, 242n2, Glycosyltransferase 8 domain-containing protein 4, GXYLT2, GLT8D4|
|Target/Specificity||This GLT8D4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-432 amino acids from the C-terminal region of human GLT8D4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLT8D4 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GXYLT2 is a xylosyltransferase (EC 2.4.2.-) that adds the first xylose to O-glucose-modified residues in the epidermal growth factor (EGF; MIM 131530) repeats of proteins such as NOTCH1 (MIM 190198) (Sethi et al., 2010 [PubMed 19940119]).
Sethi, M.K., et al. J. Biol. Chem. 285(3):1582-1586(2010)
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