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TIPIN Antibody(N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TIPIN Antibody(N-term) AP19596a
    TIPIN Antibody (N-term) (Cat. #AP19596a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TIPIN antibody detected the TIPIN protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BVW5
Other Accession NP_060328.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 34555 Da
Antigen Region 227-254 aa
Additional Information
Gene ID 54962
Other Names TIMELESS-interacting protein, TIPIN
Target/Specificity This TIPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human TIPIN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIPIN Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIPIN (HGNC:30750)
Function Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725).
Cellular Location Cytoplasm. Nucleus
Citations (0)
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Background

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.

References

Kemp, M.G., et al. J. Biol. Chem. 285(22):16562-16571(2010)
Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :
Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :
Unsal-Kacmaz, K., et al. Mol. Cell. Biol. 27(8):3131-3142(2007)
Gotter, A.L., et al. J. Mol. Biol. 366(1):36-52(2007)

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$ 182.50
$ 70.00
Cat# AP19596a
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