TIPIN Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9BVW5 |
Other Accession | NP_060328.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 34555 Da |
Antigen Region | 227-254 aa |
Gene ID | 54962 |
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Other Names | TIMELESS-interacting protein, TIPIN |
Target/Specificity | This TIPIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-254 amino acids from the N-terminal region of human TIPIN. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TIPIN Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TIPIN (HGNC:30750) |
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Function | Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:23359676, PubMed:35585232, PubMed:17102137). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:23359676, PubMed:35585232, PubMed:17102137, PubMed:17116885, PubMed:17296725). |
Cellular Location | Cytoplasm. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.
References
Kemp, M.G., et al. J. Biol. Chem. 285(22):16562-16571(2010)
Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :
Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :
Unsal-Kacmaz, K., et al. Mol. Cell. Biol. 27(8):3131-3142(2007)
Gotter, A.L., et al. J. Mol. Biol. 366(1):36-52(2007)
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