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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FADD Antibody(Center)   

FADD Antibody(Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FADD Antibody(Center) AP19607c
    FADD Antibody (Center) (Cat. #AP19607c) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the FADD antibody detected the FADD protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13158
Other Accession NP_003815.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23279 Da
Antigen Region 106-135 aa
Additional Information
Gene ID 8772
Other Names FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Target/Specificity This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFADD Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MORT1
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Location Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes
Research Areas
Citations (0)

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The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.


Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010)
Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010)
Ko, C.L., et al. Chang Gung Med J 33(2):145-151(2010)

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$ 295.00
$ 99.00
Cat# AP19607c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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