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TXNRD3 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86VQ6 |
| Other Accession | NP_001166984.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70683 Da |
| Antigen Region | 304-333 aa |
| Gene ID | 114112 |
|---|---|
| Other Names | Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2, TXNRD3 {ECO:0000312|EMBL:AAH500321} |
| Target/Specificity | This TXNRD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human TXNRD3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TXNRD3 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TXNRD3 {ECO:0000312|EMBL:AAH50032.1} |
|---|---|
| Function | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum Note=Detected in cytoplasm and nucleus in late spermatids {ECO:0000250|UniProtKB:Q99MD6} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Gerashchenko, M.V., et al. J. Biol. Chem. 285(7):4595-4602(2010)
Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)
Harris, S.E., et al. BMC Genet. 8, 43 (2007) :
Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)
Sun, Q.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(7):3673-3678(2001)
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