|Application ||WB, E|
|Calculated MW||15637 Da|
|Antigen Region||95-123 aa|
|Other Names||Hemoglobin subunit zeta, HBAZ, Hemoglobin zeta chain, Zeta-globin, HBZ, HBZ2|
|Target/Specificity||This HBZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the C-terminal region of human HBZ.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBZ Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.|
|Tissue Location||Detected in fetal erythrocytes (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'.
Hivin, P., et al. J. Cell. Sci. 118 (PT 7), 1355-1362 (2005) :
He, Z., et al. Biochem. Biophys. Res. Commun. 325(4):1376-1382(2004)
Kidd, R.D., et al. Biochemistry 40(51):15669-15675(2001)
Lau, E.T., et al. Prenat. Diagn. 21(7):529-539(2001)
Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)
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