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Dcr-1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Dcr-1 Antibody (Center) AP1961c
    Western blot analysis of Dcr-1 antibody (Center) (Cat. #AP1961c) in CEM cell line lysates (35ug/lane). Dcr-1 (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P34529
Reactivity C.Elegans
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 218423 Da
Antigen Region 1068-1097 aa
Additional Information
Gene ID 176138
Other Names Endoribonuclease dcr-1, 3126-, dcr-1
Target/Specificity This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids from the Central region of human Dcr-1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDcr-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name dcr-1
Function Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing.
Citations (0)

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The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.


Duchaine TF, et al. 2006. Cell 124:343-354.
Denli AM, et al. 2004. Nature 432:231-235.
Tabara H, et al. 2002. Cell 109:861-871.
Grishok A, et al. 2001. Cell 106:23-34.
Knight SW, et al. 2001. Science 293:2269-2271.

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$ 295.00
$ 99.00
Cat# AP1961c
(40 western blots)
Availability: In Stock
Bulk Size
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