|Application ||WB, E|
|Calculated MW||218423 Da|
|Antigen Region||1068-1097 aa|
|Other Names||Endoribonuclease dcr-1, 3126-, dcr-1|
|Target/Specificity||This Dcr-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1068-1097 amino acids from the Central region of human Dcr-1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Dcr-1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing.|
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Provided below are standard protocols that you may find useful for product applications.
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
Duchaine TF, et al. 2006. Cell 124:343-354.
Denli AM, et al. 2004. Nature 432:231-235.
Tabara H, et al. 2002. Cell 109:861-871.
Grishok A, et al. 2001. Cell 106:23-34.
Knight SW, et al. 2001. Science 293:2269-2271.
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